Endocrine Abstracts

Background: Glitazones (GZ) influence androgen biosynthesis in PCO syndrome. At present it is unknown whether a) steroid hormone metabolism is influenced by GZ in patients with type 2 diabetes b) there is a differential effect of RGZ and PGZ on steroid hormone metabolism c) this effect is sex-specific and d) this effect is mediated by changes in insulin sensitivity. Therefore, urinary steroid profiles and serum total testosterone and DHEA levels were analysed before and after ...

Background: Medical therapy with dopamine agonists (DA) is the primary treatment in most patients with prolactinomas. ‘Classical’ surgical indications are mainly intolerance of DA therapy or non-responders. Focusing on a possible shift of recent indications towards a surgical approach, we retrospectively analyzed the long-term results of surgical treatment and compared them to the medically treated female patients with prolactinomas.Patients an...

Background: In contrast to females with prolactinoma, male patients usually present with a history of long-standing hypogonadism and a macroadenoma on MRI-scan. Data is scarce about the effect of hypogonadism on bone health in these patients. We, therefore, investigated retrospectively the cohort of male patients with prolactinoma at our institution.Patients and methods: Between 1983 and 2007, the chards of 44 male patients with prolactinoma were reviewe...

Background: Surgically treated patients with NFA often present with secondary hypogonadism. Hypogonadism is a well known risk factor for osteopenia or osteoporosis. The aim of this study was to assess (a) the frequency of osteopenia/osteoporosis in a single centre Swiss cohort of patients with operated NFA and (b) whether gender or hypogonadism impacts on bone density at follow up.Methods: Data of patients with NFAs diagnosed between 1967 and 2005 were a...